RAF Typhoon FGR4s have operated alongside French warplanes in a combined operation on an underground arms cache in Syrian territory operated by the IS group, per a report from the UK Ministry of Defence.
The facility, identified by surveillance, was assessed as containing munitions and bombs, the statement said, and was located in hills just to the north of Palmyra in the heart of Syria.
"The RAF jets utilized Paveway IV guided bombs to hit a several approach shafts leading to the depot... preliminary assessments are that the strike was effective," the ministry announced.
There was no evidence of any civilian casualties in the strike conducted Saturday night and every plane involved returned to base without incident, the ministry further stated.
The British jets were supported by a Voyager tanker plane.
Daesh - alternatively referred to as Daesh - established jihadist rule over large swathes of Iraq and Syria prior to its 2019 collapse.
"This strike demonstrates British leadership, and resolve to work closely with our allies, to stamp out any re-emergence of Daesh and their harmful and extremist ideologies in the region," the British Defence Secretary the Defence Secretary stated.
British military aircraft have carried out overwatch operations over Syria to "deter any efforts to regroup" of IS following its routing at the climactic battle in Baghuz in 2019, the ministry said.
"I want to thank the personnel of the UK armed forces involved in this mission for their professionalism and their bravery," he added. "Including them were numerous British troops on duty over the festive period. This operation, to remove terrorist threats who threaten our safety, highlights how British military are ready to step up, throughout the year, keeping Britain secure at home and strong abroad."
In December, the American forces carried out what it termed a "massive strike" on IS targets in the country, after an ambush claimed the lives of two US servicemembers and a civilian interpreter in the Palmyra area.
The United Nations estimates IS still maintains an estimated 5,000 to 7,000 fighters in Syria and Iraq.